This review will focus on current treatment options, novel therapies, future approaches and ongoing clinical trials for patients with breast cancer brain metastases.īreast cancer represents the second most frequent cause of brain metastases after lung cancer, with metastases occurring in 10–16 % of patients. However, the timing and appropriate use of these therapies is controversial and careful patient selection by using available prognostic tools is extremely important. Current therapies include surgery, whole-brain radiation therapy, stereotactic radiosurgery, chemotherapy and targeted therapies. Tumor subtypes play a key role in prognosis and treatment selection. In addition, brain metastases are a major cause of morbidity, associated with progressive neurologic deficits that result in a reduced quality of life. Unfortunately, patients who develop brain metastases tend to have poor prognosis with short overall survival. Longer survival of patients with metastatic breast cancer and the use of better imaging techniques are associated with an increased incidence of brain metastases. Breast cancer is a common cause of brain metastases, with metastases occurring in at least 10–16 % of patients.
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